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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Guangtao Zhang
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Guangtao Zhang:

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - edizione con copertina flessibile

2011, ISBN: 3639309693

[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths… Altro …

NEW BOOK. Costi di spedizione: EUR 10.99 AHA-BUCH GmbH, Einbeck, Germany [51283250] [Note: 5 (sur 5)]
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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:

Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - edizione con copertina flessibile

ISBN: 9783639309690

*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival… Altro …

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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - edizione con copertina flessibile

ISBN: 3639309693

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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and ?-Helix Mimetics as Modulators of Dormancy Survival Regulator - edizione con copertina flessibile

ISBN: 9783639309690

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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - edizione con copertina flessibile

2011, ISBN: 9783639309690

Trade paperback, New., Trade paperback (US). Glued binding. 160 p., [PU: VDM Verlag]

Costi di spedizione:Costi di spedizione aggiuntivi Uxbridge, MIDDLESEX, Ria Christie Books

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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR

Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

Informazioni dettagliate del libro - Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR


EAN (ISBN-13): 9783639309690
ISBN (ISBN-10): 3639309693
Copertina rigida
Copertina flessibile
Anno di pubblicazione: 2011
Editore: VDM Verlag Dr. Müller

Libro nella banca dati dal 2009-07-01T15:06:36+02:00 (Zurich)
Pagina di dettaglio ultima modifica in 2023-06-25T11:07:36+02:00 (Zurich)
ISBN/EAN: 9783639309690

ISBN - Stili di scrittura alternativi:
3-639-30969-3, 978-3-639-30969-0
Stili di scrittura alternativi e concetti di ricerca simili:
Autore del libro : zhang
Titolo del libro: synthesis, helix


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