Derek J. Chadwick, Jamie A. Goode:Wachstumsfaktoren und psychiatrische Störungen von Novartis Foundation (englisch) Hardco
- edition reliée, livre de poche ISBN: 9780470516041
By Novartis Foundation. This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findin… Plus…
By Novartis Foundation. This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions. The Nile on eBay FREE SHIPPING UK WIDE Growth Factors and Psychiatric Disorders by Novartis Foundation The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. FORMATHardcover LANGUAGEEnglish CONDITIONBrand New Publisher Description The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that "neuregulin 1 (NRG1)"is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders. Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia. Back Cover Novartis Foundation Symposium 289 Growth factors and psychiatric disorders Chair: Moses V. Chao Psychiatric disorders such as depression, bipolar disease and schizophrenia are debilitating illnesses that are influenced by many genetic and environmental factors. While little is known about the neural circuits that underlie such disorders, the convergence of psychiatric, genetic and basic neuroscience research is providing new and exciting insights. In recent years genetic studies have identified several growth factors as susceptibility genes for depression, schizophrenia, and learning and memory. This suggests that psychiatric disorders may be influenced by a small number of genes with multiple actions. These genes will provide clues to the biochemical mechanisms and pathways that underlie these complex disorders. This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions. Topics addressed include Neuroplasticity and neurotrophic factors. Mechanisms of intracellular trafficking of growth factors. BDNF gene variants in affective disorders. Trophic factors and cognitive functions. Neurotrophins and depression. Schizophrenia genes and neuropathology. Pharmacological treatments of schizophrenia. Growth factors and psychiatric disorders will be of particular interest to psychiatrists, neurologists and geneticists, as well as cell and molecular biologists, and neuroscientists. Flap Novartis Foundation Symposium 289 Growth factors and psychiatric disorders Chair: Moses V. Chao Psychiatric disorders such as depression, bipolar disease and schizophrenia are debilitating illnesses that are influenced by many genetic and environmental factors. While little is known about the neural circuits that underlie such disorders, the convergence of psychiatric, genetic and basic neuroscience research is providing new and exciting insights. In recent years genetic studies have identified several growth factors as susceptibility genes for depression, schizophrenia, and learning and memory. This suggests that psychiatric disorders may be influenced by a small number of genes with multiple actions. These genes will provide clues to the biochemical mechanisms and pathways that underlie these complex disorders. This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions. Topics addressed include Neuroplasticity and neurotrophic factors. Mechanisms of intracellular trafficking of growth factors. BDNF gene variants in affective disorders. Trophic factors and cognitive functions. Neurotrophins and depression. Schizophrenia genes and neuropathology. Pharmacological treatments of schizophrenia. Growth factors and psychiatric disorders will be of particular interest to psychiatrists, neurologists and geneticists, as well as cell and molecular biologists, and neuroscientists. Author Biography The Novartis Foundation is an international scientific andeducational charity which promotes the study and general knowledgeof science and in particular encourages international co-operationin scientific research.Chair: MOSES V CHAO, Skirball Institute of BiomolecularMedicine, New York, USA Table of Contents Symposium on Growth factors and psychiatric disorders, held atthe Novartis Foundation, London, 20?22 March 2007.Editors: Derek J. Chadwick (Organizer) and JamieGoode.This symposium is based on a proposal made by MosesChao.Moses Chao Chair?s introduction.Daniel C. Javitt Phenomenology, aetiology and treatmentof schizophrenia.Discussion.Jonathan Flint, Sagiv Shifman, Marcus Munafo andRichard Mott Genetic variants in major depression.Discussion.Eero Castren and Tomi RantamakiNeurotrophins in depression and antidepressant effects.Discussion.Jinbo Fan and Pamela Sklar Genetics of bipolardisorder: focus on BDNF Val66Met polymorphism.Discussion.David A. Talmage Mechanisms of neuregulin action.Discussion.General discussion I.H. Akil, S. J. Evans, C. A. Turner, J. Perez, R. M. Myers, W.E. Bunney, E. G. Jones, S. J. Watson and othermembers of the Pritzker Consortium The fibroblast growth factorfamily and mood disorders.Discussion.Jay N. Giedd, Rhoshel K. Lenroot, Philip Shaw, FrancoisLalonde, Mark Celano, Samantha White, Julia Tossell, AnjeneAddington and Nitin Gogtay Trajectories of anatomicbrain development as a phenotype.Discussion.Bai Lu and Keri Martinowich Cell biology of BDNFand its relevance to schizophrenia.Discussion.Enrico Tongiorgi and Gabriele Baj Functions andmechanisms of BDNF mRNA trafficking.Discussion.Amar Sahay and Rene Hen Hippocampalneurogenesis and depression.Discussion.Andres Buonanno, Oh-Bin Kwon, Leqin Yan, CarmenGonzalez, Marines Longart, Dax Hoffman and DetlefVullhorst Neuregulins and neuronal plasticity: possiblerelevance in schizophrenia.Discussion.Zhe-Yu Chen, Kevin Bath, Bruce McEwen, Barbara Hempsteadand Francis Lee Impact of genetic variant BDNF (Val66Met) onbrain structure and function.Discussion.General discussion II.D. Malaspina, M. Perrin, K. R. Kleinhaus, M. Opler andS. Harlap Growth and schizophrenia: aetiology, epidemiologyand epigenetics.Discussion.Luiz M. Camargo, Qi Wang and Nicholas J. BrandonWhat can we learn from the disrupted in schizophrenia 1interactome: lessons for target identification and diseasebiology?Discussion.Michael Spedding and Pierre Gressens Neurotrophinsand cytokines in neuronal plasticity.Discussion.Moses Chao Closing remarks.Index of contributors.Subject index. Long Description Novartis Foundation Symposium 289 Growth factors and psychiatric disorders Chair: Moses V. Chao Psychiatric disorders such as depression, bipolar disease and schizophrenia are debilitating illnesses that are influenced by many genetic and environmental factors. While little is known about the neural circuits that underlie such disorders, the convergence of psychiatric, genetic and basic neuroscience research is providing new and exciting insights. In recent years genetic studies have identified several growth factors as susceptibility genes for depression, schizophrenia, and learning and memory. This suggests that psychiatric disorders may be influenced by a small number of genes with multiple actions. These genes will provide clues to the biochemical mechanisms and pathways that underlie these complex disorders. This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions. Topics addressed include Neuroplasticity and neurotrophic factors. Mechanisms of intracellular trafficking of growth factors. BDNF gene variants in affective disorders. Trophic factors and cognitive functions. Neurotrophins and depression. Schizophrenia genes and neuropathology. Pharmacological treatments of schizophrenia. Growth factors and psychiatric disorders will be of particular interest to psychiatrists, neurologists and geneticists, as well as cell and molecular biologists, and neuroscientists. Details ISBN0470516046 Series Novartis Foundation Symposia Language English ISBN-10 0470516046 ISBN-13 9780470516041 Media Book Format Hardcover Series Number 692 Year 2008 Publication Date 2008-03-31 DEWEY 616.89042 Illustrations Illustrations Edition 1st Pages 258 Author Novartis Foundation Audience Professional and Scholarly Publisher Wiley Country of Publication United States Short Title GROWTH FACTORS & PSYCHIATRIC D Edited by Jamie A. Goode Imprint John Wiley & Sons Inc Place of Publication New York DOI 10.1604/9780470516041 UK Release Date 2008-02-01 AU Release Date 2008-03-01 NZ Release Date 2008-03-01 US Release Date 2008-03-01 We've got thisAt The Nile, if you're looking for it, we've got it.With fast shipping, low prices, friendly service and well over a m, John Wiley & Sons INC International Concepts<
