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Patho-Epigenetics of Disease - edition reliée, livre de poche

2012, ISBN: 1461433444

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Patho-Epigenetics of Disease - edition reliée, livre de poche

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EAN (ISBN-13): 9781461433446
ISBN (ISBN-10): 1461433444
Version reliée
Date de parution: 2012
Editeur: Springer-Verlag GmbH
465 Pages
Poids: 0,852 kg
Langue: Englisch

Livre dans la base de données depuis 2007-07-24T02:05:42+02:00 (Zurich)
Page de détail modifiée en dernier sur 2022-04-27T22:44:26+02:00 (Zurich)
ISBN/EAN: 1461433444

ISBN - Autres types d'écriture:
1-4614-3344-4, 978-1-4614-3344-6
Autres types d'écriture et termes associés:
Auteur du livre: minar, helmut, nill, niller
Titre du livre: ostberlin, epigenetics and disease


Données de l'éditeur

Auteur: Janos Minarovits; Hans Helmut Niller
Titre: Patho-Epigenetics of Disease
Editeur: Springer; Springer US
466 Pages
Date de parution: 2012-05-23
New York; NY; US
Imprimé / Fabriqué en
Poids: 0,881 kg
Langue: Anglais
160,49 € (DE)
164,99 € (AT)
177,00 CHF (CH)
POD
XIV, 466 p.

BB; Medical Microbiology; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Mikrobiologie und Virologie; Verstehen; infectious diseases; Medicine/Public Health, general; Virology; Infectious Diseases; Immunology; Medical Microbiology; Health Sciences; Virology; Diseases; Immunology; Medizin, allgemein; Mikrobiologie (nicht-medizinisch); Krankheiten und Störungen; Immunologie; BC; EA

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.

Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity.

modification of histone tails.

epigenetic alterations malignant tumors epigenetic dysregulation a wide spectrum of human diseases epigenetic memory via Epigenetic regulatory mechanisms.- Role of DNMT3B Mutations in the Pathogenesis of ICF Syndrome.- Dysfunction of the Methyl-Cpg Binding Protein Mecp2 in Rett Syndrome.- Epigenetic Alterations in Glioblastoma Multiforme.- Aberrant Epigenetic Regulation in Breast Cancer.- The Impact of Epigenetic Alterations on Diagnosis, Prediction and Therapy of Prostate Cancer.- Epigenetic Reprogramming in Lung Carcinomas.- Epigenetic changes in virus associated neoplasms.- Genetic and Epigenetic Determinants of Aggression.- Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder.- Disruption of Epigenetic Mechanisms in Autoimmune Syndromes.- Imprinting Disorders.- Epigenetics of cardiovascular diseases.- Microbe-induced epigenetic alterations.

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.

Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity.

modification of histone tails.

epigenetic alterations malignant tumors epigenetic dysregulation a wide spectrum of human diseases epigenetic memory via

Patho-Epigenetics is a new discipline, and it’s covered here in detail

Written by experts in this exciting new field

Brings together recent results of epigenetic research with special attention to disease development



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