Reactive Drug Metabolites - edition reliée, livre de poche

EAN (ISBN-13): 9783527330850
ISBN (ISBN-10): 3527330852
Version reliée
Date de parution: 2012
Editeur: Wiley-VCH
386 Pages
Poids: 1,017 kg
Langue: Englisch

Livre dans la base de données depuis 2007-04-28T00:39:27+02:00 (Zurich)
Page de détail modifiée en dernier sur 2023-04-05T14:49:48+02:00 (Zurich)
ISBN/EAN: 3527330852

ISBN - Autres types d'écriture:
3-527-33085-2, 978-3-527-33085-0
Autres types d'écriture et termes associés:
Auteur du livre: scott, deepak, amit, douglas smith, dennis, raimund, hugo kubinyi, gerd folkers, kalg
Titre du livre: amit

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Données de l'éditeur

Auteur: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Titre: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Editeur: Wiley-VCH; Wiley-VCH
386 Pages
Date de parution: 2012-10-24
Imprimé / Fabriqué en
Poids: 1,000 kg
Langue: Anglais
172,00 € (DE)
Not available (reason unspecified)
170mm x 240mm x 25mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Chemie; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.