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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)
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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254) - edition reliée, livre de poche

2004

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Springer, Gebundene Ausgabe, Auflage: 2005, 351 Seiten, Publiziert: 2004-11-09T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 13285455, 3.28 kg, Thorax & Gefäßchirurgie, Chirurgie, Mediz… Plus…

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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine) - edition reliée, livre de poche

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Ryanodine Receptors - Première édition

ISBN: 9780387231877

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Springer , pp. xxi + 330 1st Edition . Hardback. New., Springer, 6

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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)
Auteur:
Titre:
ISBN:

9780387231877


In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor."In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology." David E. Clapham, MD, PhDProfessor of Neurobiology and PediatricsHarvard Medical SchoolDr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University.Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias.

Informations détaillées sur le livre - Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)


EAN (ISBN-13): 9780387231877
ISBN (ISBN-10): 0387231870
Version reliée
Livre de poche
Date de parution: 2010
Editeur: Wehrens, Xander H. T. Marks, Andrew R. Springer
330 Pages
Poids: 0,760 kg
Langue: eng/Englisch

Livre dans la base de données depuis 2007-05-30T17:52:46+02:00 (Zurich)
Page de détail modifiée en dernier sur 2024-03-06T22:29:18+01:00 (Zurich)
ISBN/EAN: 9780387231877

ISBN - Autres types d'écriture:
0-387-23187-0, 978-0-387-23187-7
Autres types d'écriture et termes associés:
Auteur du livre: wehrens, wehr, huhn, hühn susanne, wehren, xander, andre marks, andré marks
Titre du livre: development disease, dysfunction, receptors structure function, ryanodine receptors, structure and function, rya

Données de l'éditeur

Auteur: Xander H. T. Wehrens
Titre: Developments in Cardiovascular Medicine; Ryanodine Receptors - Structure, function and dysfunction in clinical disease
Editeur: Springer; Springer US
330 Pages
Date de parution: 2004-11-09
New York; NY; US
Langue: Anglais
164,99 € (DE)

BB; Hardcover, Softcover / Medizin/Klinische Fächer; Kardiologie, Angiologie; Verstehen; cardiovascular; pathophysiology; physiology; skeletal muscle; smooth muscle; Cardiology; EA; BC

Evolution of the Ryanodine Receptor Gene Family.- Topology and Transmembrane Organization of Ryanodine Receptors.- Three-Dimensional Reconstruction of Ryanodine Receptors.- RYR-DHPR Relationships in Skeletal and Cardiac Muscles.- The Pore of the Ryanodine Receptor Channel.- Intra-Molecular Domain-Domain Interaction.- Regulation of Sarcoplasmic Reticulum Calcium Release by Luminal Calcium.- Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels.- Elementary Ca2+ Release Events: Ryanodine Receptor Ca2+ Sparks.- Ca2+ Release from the Sarcoplasmic Reticulum in Intact Cardiomyocytes.- Stability and Instability of Ca2+ Release from the SR.- Ryanodine Receptors in Smooth Muscle.- Functions of RYR3 Homologues.- Knockout Mice Lacking RYR and Junctophilin Subtypes.- Regulation of Ryanodine Receptor Ca2+ Release by Macromolecular Complexes.- RYR1 Modulation by Calmodulin.- Ryanodine Receptor Function in Inflammation.- Ryanoids, Receptor Affinity and RYR Channel Subconductance.- Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function.- Redox Sensing by the Ryanodine Receptors.- Ryanodine Receptor Dysfunction in the Diabetic Heart.- Molecular and Clinical Genetics of RYR1 Disorders.- Pathophysiology of Muscle Disorders Linked to Mutations in the Skeletal Muscle Ryanodine Receptor.- The Dantrolene Binding Site on RYR1.- Ryanodine Receptor Dysfunction in Heart Failure and Arrhythmias.- Stabilization of Ryanodine Receptor as a Novel Therapeutic Strategy Against Heart Failure.- Ryanodine Receptor Antibodies and Myasthenia Gravis.

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