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Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules Janice Aldrich-Wright Editor
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9783211990797

Informations détaillées sur le livre - Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules Janice Aldrich-Wright Editor


EAN (ISBN-13): 9783211990797
ISBN (ISBN-10): 3211990798
Date de parution: 2011
Editeur: Springer Vienna Digital >16
427 Pages
Langue: eng/Englisch

Livre dans la base de données depuis 2011-08-22T21:33:31+02:00 (Zurich)
Page de détail modifiée en dernier sur 2023-11-25T13:39:22+01:00 (Zurich)
ISBN/EAN: 9783211990797

ISBN - Autres types d'écriture:
3-211-99079-8, 978-3-211-99079-7
Autres types d'écriture et termes associés:
Auteur du livre: jan aldrich, janice, ald, will wright
Titre du livre: probe

Données de l'éditeur

Auteur: Janice Aldrich-Wright
Titre: Metallointercalators - Synthesis and Techniques to Probe Their Interactions with Biomolecules
Editeur: Springer; Springer Wien
427 Pages
Date de parution: 2011-04-06
Vienna
Langue: Anglais
149,79 € (DE)
149,79 € (AT)
177,00 CHF (CH)
Available
XXVIII, 427 p.

EA; E107; eBook; Nonbooks, PBS / Chemie/Anorganische Chemie; Anorganische Chemie; Verstehen; Biomolecular drug design; Inorganic Chemistry; Metallointercalator probe techniques; Metallointercalator synthesis; Metallointercalators; Physical Chemistry; B; Inorganic Chemistry; Pharmacy; Biochemistry; Physical Chemistry; Spectroscopy; Chemistry and Materials Science; Pharmazie, Apotheke; Biochemie; Physikalische Chemie; Spektroskopie, Spektrochemie, Massenspektrometrie; BB

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Introduction.- Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers.- Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing.

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.


Provides a detailed exposition on the propaedeutics and techniques illustrated with cogent examples Includes supplementary material: sn.pub/extras

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