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2013

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Pharmacotherapy of Pulmonary Hypertension
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9783642386640

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EAN (ISBN-13): 9783642386640
ISBN (ISBN-10): 3642386644
Date de parution: 2013
Editeur: Springer Berlin
576 Pages
Langue: eng/Englisch

Livre dans la base de données depuis 2012-03-01T01:35:45+01:00 (Zurich)
Page de détail modifiée en dernier sur 2022-08-31T08:52:56+02:00 (Zurich)
ISBN/EAN: 9783642386640

ISBN - Autres types d'écriture:
3-642-38664-4, 978-3-642-38664-0
Autres types d'écriture et termes associés:
Auteur du livre: johannes peter, humbert, stasch, johann peter, hum, stas peter, staß, marc peter
Titre du livre: hype, hypertension

Données de l'éditeur

Auteur: Marc Humbert; Oleg V. Evgenov; Johannes-Peter Stasch
Titre: Handbook of Experimental Pharmacology; Pharmacotherapy of Pulmonary Hypertension
Editeur: Springer; Springer Berlin
576 Pages
Date de parution: 2013-10-04
Berlin; Heidelberg; DE
Imprimé / Fabriqué en
Langue: Anglais
Available
IX, 576 p. 66 illus., 56 illus. in color.

EA; E107; eBook; Nonbooks, PBS / Medizin/Pharmazie; Pharmakologie; Verstehen; Vasoactive substances; WHO Group I-V; lung vasculature; pulmonary artery; pulmonary hypertension (PH); pulmonary vein; C; Pharmacology/Toxicology; Pharmaceutical Sciences/Technology; Internal Medicine; Pneumology/Respiratory System; Laboratory Medicine; Molecular Medicine; Pharmacology; Pharmaceutics; Internal Medicine; Pneumology; Biomedical Research; Biomedical and Life Sciences; Medizinische Chemie, Pharmazeutische Chemie; Klinische und Innere Medizin; Lungen- und Bronchialheilkunde; Medizinische Forschung; BB

Over the past decade, major advancements in the understanding of the molecular mechanisms and pathophysiology of pulmonary hypertension occurred in parallel with the discovery and development of new therapies. Pharmacological agents that modulate the main pathophysiological pathways of pulmonary arterial hypertension have changed the course of this devastating disease by relieving symptoms and improving and prolonging patients’ lives.

The first part of the book covers definition, classification, pathophysiology, pathology, biomarkers and animal models of pulmonary hypertension, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The concluding section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotides homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to clinical applications of these experimental therapies.

Preface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models.- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors.- Part III. Pulmonary hypertension: novel pathways and emerging therapies     Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy.- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.

Written by leading experts in the field of pulmonary hypertension

Broadens your understanding of current, evidence-based pharmacological treatments of various forms of pulmonary hypertension

Comprehensive review of most recent developments in this field including new signaling pathways

Includes supplementary material: sn.pub/extras


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