Cancer Biomarkers - edition reliée, livre de poche

EAN (ISBN-13): 9780471745167
ISBN (ISBN-10): 0471745162
Version reliée
Date de parution: 2007
Editeur: Wiley-Interscience
377 Pages
Poids: 0,694 kg
Langue: eng/Englisch

Livre dans la base de données depuis 2007-12-01T21:30:38+01:00 (Zurich)
Page de détail modifiée en dernier sur 2024-01-04T00:27:28+01:00 (Zurich)
ISBN/EAN: 9780471745167

ISBN - Autres types d'écriture:
0-471-74516-2, 978-0-471-74516-7
Autres types d'écriture et termes associés:
Auteur du livre: mahmoud, desi, hamdan
Titre du livre: cancer biomarkers, biomarker

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Données de l'éditeur

Auteur: Mahmoud H. Hamdan
Titre: Wiley-Interscience Series on Mass Spectrometry; Cancer Biomarkers - Analytical Techniques for Discovery
Editeur: John Wiley & Sons
378 Pages
Date de parution: 2007-03-02
Poids: 0,703 kg
Langue: Anglais
145,00 € (DE)
No longer receiving updates
165mm x 239mm x 24mm

BB; gebunden; Hardcover, Softcover / Chemie; Spektroskopie, Spektrochemie, Massenspektrometrie; Mass Spectrometry; Biowissenschaften; Medizin; Onkologie u. Strahlentherapie; Oncology & Radiotherapy; Chemie; Proteomics; Life Sciences; Chemistry; Onkologie; Genomforschung u. Proteomik; Massenspektrometrie; Massenspektroskopie; Genomics & Proteomics; Medical Science; Massenspektrometrie; Genomforschung u. Proteomik; Onkologie u. Strahlentherapie

Preface. Acknowledgments. Introduction. 1 Overview. 1.1. Introduction. 1.2. Cancer Biomarkers. 1.3. Phases of Biomarkers Development. 1.4. New Approach to Biomarkers Discovery. 1.5. Initiatives Relevant to Biomarkers Discovery. 1.6. Concluding Remarks. References. 2 Proteomic Platforms for Biomarkers Discovery. 2.1. Surface Enhanced Laser Desorption Ionization. 2.2. Bioinformatics in SELDI. 2.3. Some Representative SELDI Applications. 2.4. Two-dimensional Polyacrylamide Gel Electrophoresis. 2.5. Laser Capture Microdissection. 2.6. MS Analysis of Gel-separated Proteins. 2.7. Representative Applications of 2-DE for Biomarkers Discovery. 2.8. Protein Microarrays. 2.9. Multidimensional Liquid Chromatography Coupled to MS. 2.10. Chromatographic Separation. 2.11. Imaging Mass Spectrometry. References. 3 Some Existing Cancer Biomarkers. 3.1. Introduction. 3.2. Historic Glimpse at PSA. 3.3. Prostate-specifi c Antigen. 3.4. PSA as a Screening Marker. 3.5. Improving the Specifi city of PSA. 3.6. Looking for Other Solutions. 3.7. Concluding Remarks. 3.8. Existing Biomarkers for Ovarian Cancer. 3.9. Osteopontin. 3.10. Combination of CA-125 with Other Potential Biomarkers. 3.11. Profi ling Proteins and Gene Expression in Ovarian Cancer. 3.12. General Observations. References. 4 Potential Cancer Biomarkers. 4.1. Introduction. 4.2. Human Tissue Kallikreins. 4.3. Protein Family 14-3-3. 4.4. Heat Shock Proteins (HSPs). 4.5. Heat Shock Protein 27 (HSP27). 4.6. Heat Shock Protein 70 (HSP70). 4.7. General Remarks. 4.8. Calcium Binding Proteins. 4.9. DNA Methylation. 4.10. DNA Methylation in Cancer. 4.11. Inhibition of DNA Methylation. 4.12. Concluding Remarks. References. 5 Protein Networks and Protein Phosphorylation in Cancer. 5.1. Introduction. 5.2. Protein Interaction Networks. 5.3. Computational Approaches. 5.4. Human Protein Intractome. 5.5. Relationship Between Gene Expression and Protein Interaction. 5.6. Gene Signatures in Cancer Prediction/Classifi cation. 5.7. Concluding Remarks. 5.8. Protein Phosphorylation. 5.9. Other Approaches. 5.10. The Phosphatidylinositol 3-Kinase-Akt Pathway (PI3K-Akt). 5.11. PIK3/Akt Alterations and Prognostic Biomarkers. 5.12. General Observations. References. 6 Ethical Issues and Initiatives Relevant to Cancer Biomarkers. 6.1. Introduction. 6.2. Background. 6.3. Ethical Committees/Organizations. 6.4. Human Biobanks. 6.5. Large Population Screening. 6.6. Genetic Testing for Cancer Susceptibility. 6.7. Ethics in Phase I Oncology Trials. 6.8. Initiatives Relevant to Biomarkers Discovery. 6.9. Genomic Initiatives/Resources. 6.10. Achievements and Perspectives. References. Abbreviations. Index.