Devarakonda R. Krishna, Ulrich Klotz:Clinical Pharmacokinetics, A Short Introduction
- nouveau livre ISBN: 9783540524588
The first part of this book enables the reader to be familiarized with basic concepts of pharmacokinetics (Absorption, Distribution, Metabolism and Excretion - ADM E) following single dos… Plus…
The first part of this book enables the reader to be familiarized with basic concepts of pharmacokinetics (Absorption, Distribution, Metabolism and Excretion - ADM E) following single dose administration. In this part these principles are applied to clinically relevant situations, namely, multiple or (sub) chronic administration. In day to day practice besides acute drug response, often a longer duration of action is desired. This situation needs the under standing of changes in pharmacokinetics of drugs upon repeated administra tion, and the dosage regimen has to be accordingly adjusted for achieving uniform therapeutic levels for desired period of time. 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also valid (with slight modifications) for multiple dose kinetics. In multiple dose therapy the ultimate purpose is to achieve a steady drug effect or response with minimum side effects. As mentioned before, this can be achieved in most cases by maintaining the plasma concentrations in therapeutic range for required number of hours or days. This may be considered as a general rule with an exception of nitrates, in which case the concentrations during the interval between two doses (called "dosing interval") should fall below a critical threshold level, such that tolerance does not develop. A drug is commonly administered in fixed doses at constant intervals of time so that the amount lost through elimination is replaced after each dose. The first part of this book enables the reader to be familiarized with basic concepts of pharmacokinetics (Absorption, Distribution, Metabolism and Excretion - ADM E) following single dose administration. In this part these principles are applied to clinically relevant situations, namely, multiple or (sub) chronic administration. In day to day practice besides acute drug response, often a longer duration of action is desired. This situation needs the under standing of changes in pharmacokinetics of drugs upon repeated administra tion, and the dosage regimen has to be accordingly adjusted for achieving uniform therapeutic levels for desired period of time. 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also valid (with slight modifications) for multiple dose kinetics. In multiple dose therapy the ultimate purpose is to achieve a steady drug effect or response with minimum side effects. As mentioned before, this can be achieved in most cases by maintaining the plasma concentrations in therapeutic range for required number of hours or days. This may be considered as a general rule with an exception of nitrates, in which case the concentrations during the interval between two doses (called "dosing interval") should fall below a critical threshold level, such that tolerance does not develop. A drug is commonly administered in fixed doses at constant intervals of time so that the amount lost through elimination is replaced after each dose. Inhoud: Taal: Engels; Bindwijze: Paperback; Druk: Softcover reprint of the original 1st ed. 1990; Verschijningsdatum: juli 1990; Aantal pagina's: 149 pagina's; Illustraties: Nee; Betrokkenen: Auteur(s): Devarakonda R. Krishna | Ulrich Klotz | D. R. Krishna; Uitgever: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG; EAN: Overige kenmerken: Extra groot lettertype: Nee; Gewicht: 280 g; Verpakking breedte: 155 mm; Verpakking hoogte: 0 mm; Verpakking lengte: 235 mm; Engels | Druk: Softcover reprint of the original 1st ed. 1990 | Paperback | 9783540524588 | 149 pagina's, Boeken, Geneeskunde & Verpleging, Specialistische geneeskunde, Farmacologie, Klinische & Interne geneeskunde, Springer-Verlag Berlin and Heidelberg GmbH & Co. KG<
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Klotz, Ulrich; Krishna, Devarakonda R.:Clinical Pharmacokinetics A Short Introduction
- Livres de poche 1990, ISBN: 3540524584
Softcover reprint of the original 1st ed. 1990 Kartoniert / Broschiert Klinische und Innere Medizin, Arzneimittelbehandlung; Arzneimittelevaluierung; Dosierungsberechnungen; Pharmakokin… Plus…
Softcover reprint of the original 1st ed. 1990 Kartoniert / Broschiert Klinische und Innere Medizin, Arzneimittelbehandlung; Arzneimittelevaluierung; Dosierungsberechnungen; Pharmakokinetik, mit Schutzumschlag 11, [PU:Springer Berlin Heidelberg; Springer-Verlag GmbH]<
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Klotz, Ulrich; Krishna, Devarakonda R.:Clinical Pharmacokinetics A Short Introduction
- Livres de poche 1990, ISBN: 3540524584
Softcover reprint of the original 1st ed. 1990 Kartoniert / Broschiert Klinische und Innere Medizin, Arzneimittelbehandlung; Arzneimittelevaluierung; Dosierungsberechnungen; Pharmakokin… Plus…
Softcover reprint of the original 1st ed. 1990 Kartoniert / Broschiert Klinische und Innere Medizin, Arzneimittelbehandlung; Arzneimittelevaluierung; Dosierungsberechnungen; Pharmakokinetik, mit Schutzumschlag neu, [PU:Springer Berlin Heidelberg; Springer Berlin]<
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Devarakonda R. Krishna:Clinical Pharmacokinetics
- Livres de poche ISBN: 9783540524588
Paperback, [PU: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG], 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also val… Plus…
Paperback, [PU: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG], 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also valid (with slight modifications) for multiple dose kinetics., Pharmacology<
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Devarakonda R. Krishna; Ulrich Klotz:Clinical Pharmacokinetics
- Livres de poche 1990, ISBN: 9783540524588
A Short Introduction, Buch, Softcover, Softcover reprint of the original 1st ed. 1990, [PU: Springer Berlin], Springer Berlin, 1990
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